Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists

Nafizal Hossain; Svetlana Ivanova; Jonas Bergare; Marguérite Mensonides-Harsema; Martin E Cooper

doi:10.1016/j.bmcl.2013.04.047

Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3500-4. doi: 10.1016/j.bmcl.2013.04.047. Epub 2013 Apr 28.

Authors

Nafizal Hossain¹, Svetlana Ivanova, Jonas Bergare, Marguérite Mensonides-Harsema, Martin E Cooper

Affiliation

¹ Department of Medicinal Chemistry, RIA Innovative Medicines, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. nafizal.hossain@astrazeneca.com

PMID: 23659855
DOI: 10.1016/j.bmcl.2013.04.047

Abstract

A series of CCR1 antagonists based upon spirocyclic compounds 1b and 2b were synthesised in which substituted aniline moiety was replaced with substituted benzamides. In vitro data revealed that CCR1 potency could be retained in such compounds.

Publication types

Letter

MeSH terms

Drug Design
Humans
Receptors, CCR1 / antagonists & inhibitors*
Receptors, CCR1 / chemistry
Spiro Compounds / chemical synthesis
Spiro Compounds / chemistry*
Spiro Compounds / pharmacology*
Structure-Activity Relationship

Substances

Receptors, CCR1
Spiro Compounds